Karl Heinz Weiss Selected Research

Copper

1/2023	Neurological worsening in Wilson disease - clinical classification and outcome.
1/2023	Medical care of patients with Wilson disease in Germany: a multidisciplinary survey among university centers.
12/2022	Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.
1/2022	Synonymous mutation in adenosine triphosphatase copper-transporting beta causes enhanced exon skipping in Wilson disease.
1/2022	Multicentre, retrospective study to assess long-term outcomes of chelator based treatment with trientine in Wilson disease patients withdrawn from therapy with d -penicillamine.
12/2021	Designing Clinical Trials in Wilson's Disease.
9/2021	Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects.
1/2021	The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study.
11/2019	Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta-analysis of controlled studies.
5/2019	Biochemical Markers for the Diagnosis and Monitoring of Wilson Disease.

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Karl Heinz Weiss Research Topics

Disease

46	Hepatolenticular Degeneration (Wilson's Disease) 02/2023 - 04/2006
16	Neoplasms (Cancer) 06/2020 - 12/2009
15	Liver Diseases (Liver Disease) 01/2020 - 09/2007
14	Fibrosis (Cirrhosis) 01/2022 - 09/2007
12	Hepatocellular Carcinoma (Hepatoma) 11/2022 - 01/2014
10	Cholangiocarcinoma 12/2022 - 08/2017
9	Sclerosing Cholangitis 01/2020 - 01/2012
7	End Stage Liver Disease 01/2020 - 09/2007
6	Infections 03/2021 - 09/2007
4	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 09/2007
4	Disease Progression 10/2021 - 08/2016
4	Biliary Tract Neoplasms (Biliary Tract Cancer) 06/2020 - 02/2016
4	Pathologic Constriction (Stenosis) 01/2020 - 01/2016
4	Hepatitis 09/2018 - 09/2007
4	Inborn Genetic Diseases (Disease, Hereditary) 06/2018 - 12/2008
4	Cholangitis 01/2017 - 10/2013
4	Liver Failure 01/2012 - 09/2007
3	Liver Neoplasms (Liver Cancer) 12/2022 - 08/2017
3	Neurologic Manifestations (Neurological Manifestations) 01/2022 - 08/2013
3	Ascites 01/2021 - 09/2009
3	Inflammation (Inflammations) 11/2020 - 01/2012
2	Adenocarcinoma 10/2020 - 06/2020
2	Hepatitis C 01/2020 - 10/2018
2	Microsatellite Instability 01/2019 - 09/2017
2	Virus Diseases (Viral Diseases) 06/2018 - 09/2007
2	Chronic Hepatitis C 01/2017 - 01/2017
2	Cholestasis 12/2015 - 10/2008
2	Peritonitis 10/2015 - 07/2013
2	Iron Overload 01/2012 - 09/2007
2	Brain Diseases (Brain Disorder) 09/2009 - 09/2007
1	Abdominal Pain (Pain, Abdominal) 12/2022
1	Headache (Headaches) 12/2022
1	Exanthema (Rash) 12/2022
1	Leukopenia 12/2022
1	Nausea 11/2022
1	Anemia 01/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Hypertrophy 01/2021
1	Hirsutism 01/2021
1	Ulcerative Colitis 01/2021
1	Hemorrhage 01/2021
1	Portal Hypertension 01/2021
1	Invasive Fungal Infections 11/2020
1	Viremia 07/2020
1	Stomach Neoplasms (Stomach Cancer) 06/2020
1	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 01/2020
1	Autoimmune Hepatitis 01/2020
1	Brain Death (Brain Dead) 01/2020

Drug/Important Bio-Agent (IBA)

38	CopperIBA 01/2023 - 04/2006
7	Trientine (Trien)FDA Link 02/2023 - 08/2013
6	Chelating AgentsIBA 01/2022 - 04/2011
6	Biomarkers (Surrogate Marker)IBA 11/2020 - 12/2015
5	Ceruloplasmin (Ferroxidase)IBA 01/2019 - 04/2006
4	Penicillamine (Cuprimine)FDA Link 12/2022 - 08/2013
4	ZincIBA 01/2022 - 04/2011
4	Adenosine Triphosphatases (ATPase)IBA 01/2022 - 07/2008
4	AntigensIBA 01/2019 - 06/2015
3	Transaminases (Aminotransferases)IBA 01/2021 - 12/2017
3	Sorafenib (BAY 43-9006)FDA Link 11/2019 - 09/2018
3	Immune Checkpoint InhibitorsIBA 05/2019 - 09/2017
3	Antiviral Agents (Antivirals)IBA 10/2018 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 03/2016 - 07/2008
3	FucosyltransferasesIBA 02/2016 - 12/2013
2	AcyltransferasesIBA 01/2022 - 10/2018
2	infigratinibIBA 10/2021 - 01/2018
2	Gemcitabine FDA Link 10/2021 - 01/2018
2	IronIBA 01/2021 - 01/2012
2	Cell Adhesion MoleculesIBA 11/2020 - 08/2017
2	DNA (Deoxyribonucleic Acid)IBA 07/2020 - 09/2017
2	Bile Pigments (Bilin)IBA 06/2020 - 12/2019
2	serum P-component (CIt)IBA 01/2020 - 09/2018
2	Phospholipases (Phospholipase)IBA 01/2020 - 10/2018
2	CarbohydratesIBA 01/2019 - 12/2015
2	BilirubinIBA 09/2018 - 09/2009
2	Carcinoembryonic AntigenIBA 01/2017 - 02/2016
1	Alanine Transaminase (SGPT)IBA 11/2022
1	degradable starch microspheresIBA 11/2022
1	Apolipoproteins E (ApoE)IBA 01/2022
1	ApolipoproteinsIBA 01/2022
1	amidoximeIBA 01/2022
1	ProcalcitoninIBA 11/2020
1	C-Reactive ProteinIBA 11/2020
1	RNA (Ribonucleic Acid)IBA 10/2020
1	Immunosuppressive Agents (Immunosuppressants)IBA 09/2020
1	Valganciclovir FDA Link 07/2020
1	Ganciclovir (Cytovene)FDA LinkGeneric 07/2020
1	human ERBB2 proteinIBA 06/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Methylmalonic AcidIBA 01/2020
1	CytokinesIBA 01/2020
1	HomocysteineIBA 01/2020
1	Oxidoreductases (Dehydrogenase)IBA 01/2020

Therapy/Procedure

30	Liver Transplantation 11/2022 - 09/2007
24	Therapeutics 01/2023 - 09/2007
9	Transplantation 09/2020 - 09/2007
4	Drug Therapy (Chemotherapy) 12/2019 - 08/2017
3	Transjugular Intrahepatic Portasystemic Shunt 01/2021 - 03/2010
2	Surgical Portasystemic Shunt (Portosystemic Shunt) 01/2021 - 08/2010
1	Chelation Therapy (Therapy, Chelation) 01/2023
1	Palliative Care (Palliative Therapy) 11/2022